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“We aim to pave the path to HIV elimination through the entry point of improving community health.”

 

Diane Havlir, MD,

Principal Investigator

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INFO

Mission

SEARCH engages communities and local leadership in a multi-disease approach to improve health screening, care delivery and individual and community well-being.

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The research study uses bold, new ideas—like multi-disease, community-based testing and treatment—to address more than HIV, including community health, economic productivity, and cultural stigma.

SEARCH SAPPHIRE
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The SEARCH team is excited to announce a new 5-year NIH-funded research program designed to design and test evidence based treatment and prevention interventions that will guide a global effort to end AIDS using a multi-disease, multi-sector approach. The new program, SEARCH Sapphire: “A Multisectoral Strategy to Address Persistent drivers of the HIV epidemic in East Africa” aims to accelerate the path to HIV elimination with new innovative combination strategies for HIV prevention and treatment that are effective, efficient, scalable and reduce preventable infections and deaths. Collaborators for this study include Kenya Medical Research Institute in Kenya, Infectious Diseases Research Collaboration and Makerere University in Uganda, University of California Berkeley, University of Massachusetts Amherst, University of Pennsylvania, and University College London and will start in early 2021!

SEARCH team at AIDS 2018 conference in Amsterdam

What is SEARCH?

SEARCH (Sustainable East Africa Research in Community Health) is a multinational, multidisciplinary consortium assembled to conduct research that evaluates bold health interventions at the community level that inform policy makers and funding agencies through the inclusion of health, economic and education parameters and through innovative, efficient study designs. SEARCH currently is located in multiple communities in rural Uganda and Kenya.

 

The study is considering the health, economic and educational impact of new approaches in community HIV testing, treatment, care and prevention. In the first phase of SEARCH (2013-2017), the research team worked with local communities to host mobile, community-wide health fairs that included health education; screenings for HIV and diseases like hypertension, diabetes, and tuberculosis; and immediate care or referral for any health problems. In the second phase (2017-2020), the team used targeted HIV prevention (i.e., PrEP, or Pre-Exposure Prophylaxis), targeted HIV testing, and targeted care interventions on top of universal treatment and streamlined care. In the upcoming SAPPHIRE study, the team aims to accelerate the path to HIV elimination with new innovative combination strategies for HIV prevention and treatment that are effective, efficient, scalable and reduce preventable infections and deaths.

The results of SEARCH will help to guide the global effort to end AIDS. 

Background
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Despite effective treatments, in 2018, only 24.5 million of the 38 million people living with HIV globally receive treatment. This gap exists largely because health workers in developing countries struggle to reach HIV-infected individuals. SEARCH interventions are designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most “at risk” and build upon evidence based prevention interventions.  This information will guide a global effort to end AIDS.  

OPPORTUNITY

Now & the Future
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SEARCH represents an opportunity to realize HIV elimination and to improve community health and productivity.

SEARCH Phase I (2013-2017) showed that multi-disease, community-based testing and treatment is effective and can reduce deaths and new HIV infections and increase workforce participation.

 

SEARCH Phase II (2017-2020) focused on new  health and treatment models for adolescents and young adults; HIV Pre-Exposure Prophylaxis (PrEP); treatment models for tuberculosis; and novel electronic technologies for community health.

SEARCH SAPPHIRE (2021-2026) aims to accelerate the path to HIV elimination with new innovative combination strategies for HIV prevention and treatment that are effective, efficient, scalable and reduce preventable infections and deaths.

IMPACT

SEARCH Science

PEOPLE

Leadership

SEARCH Phase II Findings Published in PLoS Med

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The SEARCH Collaboration published important Phase II findings "HIV incidence after pre-exposure prophylaxis initiation among women and men at elevated HIV risk: A population-based study in rural Kenya and Uganda" in the prestigious PLoSMed journal. SEARCH found that population-level offer of  oral pre-exposure prophylaxis (PrEP) with rapid start and flexible service delivery was associated with 74% lower HIV incidence. HIV infections were significantly lower among women who started PrEP. Universal HIV testing with linkage to treatment and prevention, including PrEP, is a promising approach to accelerate reductions in new infections.

You can read the full article here

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Diane Havlir, MD

Principal Investigator

Professor of Medicine and Chief, Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General Hospital, University  of California,  San Francisco

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Moses Kamya, MBChB, MMed, MPH, PhD

Co-Principal Investigator

Professor of Medicine and current Chair of the Department of Medicine at Makerere University College of Health Sciences in Kampala, Uganda

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Maya Petersen, MD, PhD

Co-Principal Investigator

Associate Professor of Biostatistics and Epidemiology and Chair of Epidemiology at the School of Public Health, University of California, Berkeley

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Dr. Catherine Koss of University of California, San Francisco presented at the 2020 AIDS Conference in San Francisco on behalf of the SEARCH team on SEARCH trial Phase II interim results.The results show  that population-level PrEP offer (2016-2019) in 16 communities in rural Uganda and Kenya was associated with lower HIV incidence among PrEP initiators with follow-up HIV testing than among recent (2015-2017) matched controls in the absence of PrEP.

Scientific Abstract and Presentation: https://cattendee.abstractsonline.com/meeting/9289/presentation/202

SEARCH Phase I Main Findings Published in New England Journal of Medicine

The SEARCH Collaboration published its Phase I findings "HIV Testing and Treatment with the Use of a Community Health Approach" in the prestigious New England Journal of Medicine. In conjunction with two other published studies, we now know that a Universal Test and Treat strategy can significantly reduce HIV incidence.  SEARCH showed that a multi-disease approach adds community health benefits of reducing tuberculosis and mortality along with reductions in new HIV infections. We also know that we will need more than test and treat alone to eliminate HIV and that is why we continue important work in the SEARCH study. 

See SEARCH profiled in the Emmy-winning episode of the PBS Newshour  click below

SEARCH study exceeds U.N.  'test and treat' goal for ending HIV pandemic

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SEARCH Research has produced Over 70 peer-reviewed publications since 2014

SEARCH Program Highlights

Click on Article Title to Get PDF File of publication.
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Investigative Team
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Gabriel Chamie, MD, MPH

Study Vice Chair / Investigator

University of California, San Francisco

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James Ayieko, MBChB, MPH, PhD

Investigator

Kenya Medical Research Institute

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Laura Balzer, PhD

Study Statistician / Investigator

U Mass Amherst

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Elizabeth Bukusi, MBChB, MMed, MPH, PhD

Kenya Site PI / Investigator

Kenya Medical Research Institute

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Carol Camlin, MPH, PhD

Investigator

University of California, San Francisco

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Edwin Charlebois, MPH, PhD

 Investigator

University of California, San Francisco

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Tamara Clark, MHS

Executive Administrator /Investigator

University of California, San Francisco

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Craig Cohen, MD, MPH

Investigator

University of California, San Francisco

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Eric Goosby, MD

Investigator

University of California, San Francisco

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Judy Hahn, MA, PhD

Investigator

University of California, San Francisco

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Priscilla Hsue, MD

Investigator

University of California, San Francisco

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Jane Kabami, MPH

Investigator

Infectious Diseases Research Collaboration, Uganda

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Elijah Kakande, MBChB, MPH

Investigator

Infectious Diseases Research Collaboration

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Catherine Koss, MD

Investigator

University of California, San Francisco

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Florence Mwangwa, MBChB, MPH

Investigator

Infectious Diseases Research Collaboration

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Marilyn Nyabuti, MBChB

Investigator

Kenya Medical Research Institute 

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Asiphas Owaraganise, MBChB, MMed

Investigator

Infectious Diseases Research Collaboration

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Andrew Phillips, MSc, PhD

Modelling / Investigator

University College London

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Theodore Ruel, MD

Investigator

University of California, San Francisco

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Norton Sang, MA

Investigator

Kenya Medical Research Institute 

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Starley Shade, MPH, PhD

Investigator

University of California, San Francisco

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Harsha Thurimurthy, PhD

Economist / Investigator 

University of Pennsylvania

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