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+1-415-206-8790

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1001 Potrero Ave., Building 80, Ward 84 

San Francisco, CA 94110

Updated 15 January 2019

“We aim to pave the path to HIV elimination through the entry point of improving community health.”

 

Diane Havlir, MD,

Principal Investigator

INFO

Mission

SEARCH engages communities and local leadership in a multi-disease approach to improve health screening, care delivery and individual and community well-being.

The research study uses bold, new ideas—like multi-disease, community-based testing and treatment—to address more than HIV, including community health, economic productivity, and cultural stigma.

What is SEARCH?

SEARCH is a research study that uses the “Test-and-Treat” strategy for HIV reduction—that is, we screen for HIV in all persons in a community, followed by immediate treatment for those who test positive—in 32 communities in rural Uganda and Kenya, including over 350,000 adults and children.

 

The study is considering the health, economic and educational impact of new approaches in community HIV testing, treatment, care and prevention. In the first phase of SEARCH (2013-2017), the research team worked with local communities to host mobile, community-wide health fairs that included health education; screenings for HIV and diseases like hypertension, diabetes, and tuberculosis; and immediate care or referral for any health problems. In the second phase (2017-2020), the team is using targeted HIV prevention (i.e., PrEP, or Pre-Exposure Prophylaxis), targeted HIV testing, and targeted care interventions on top of universal treatment and streamlined care.

 

The results of SEARCH will help to guide the global effort to end AIDS. 

Locations
Background

Despite effective treatments, only 22 million of the 37 million people living with HIV globally receive treatment. This gap exists largely because health workers in developing countries struggle to reach HIV-infected individuals. In the first phase of the SEARCH trial (2013-2017), mobile, community-wide health fairs offered annual testing for HIV, tuberculosis, malaria, high blood pressure and diabetes.

Collaborators & Advisors

IMPACT

SEARCH Phase 1 Main Findings Published in New England Journal of Medicine

The SEARCH Collaboration has recently published its Phase I findings "HIV Testing and Treatment with the Use of a Community Health Approach" in the prestigious New England Journal of Medicine. In conjunction with two other published studies, we now know that a Universal Test and Treat strategy can significantly reduce HIV incidence.  We showed in SEARCH that a multi-disease approach adds community health benefits of reducing tuberculosis and mortality along with reductions in new HIV infections. We also know that we will need more than test and treat alone to eliminate HIV and that is why we continue important work in the SEARCH study. This publication adds to the over 50 papers that have been published by the SEARCH Collaboration in the past few years.


You can access the new publication here: https://www.nejm.org/doi/10.1056/NEJMoa1809866

SEARCH Presents Intervention Results Showing 27% Reduction in Mortality among HIV infected Men at CROI 2019 Conference

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Dr. Moses Kamya of Makerere University, Uganda presented at the 2019 International Conference on Retroviruses and Opportunistic Infections in Seattle on behalf of the SEARCH Test-and-Treat trial showing that the study’s approach to streamlined HIV care significantly accelerated treatment start and reduced mortality at a population level among HIV+ persons with advanced disease with strong effects particularly among men.

 

Scientific Abstract: http://www.croiconference.org/sessions/search-intervention-reduces-mortality-population-level-men-low-cd4-count

Webcast Link: 

http://www.croiwebcasts.org/p/2019croi/138

See SEARCH profiled in the Emmy-winning episode of the PBS Newshour

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SEARCH study exceeds U.N.  'test and treat' goal for ending HIV pandemic

SEARCH Research has produced Over 50 peer-reviewed publications since 2014

Recent Highlights

Click on Article Title to Get PDF File of publication.

SEARCH Science

OPPORTUNITY

Now & the Future

SEARCH represents an opportunity to realize HIV elimination and to improve community health and productivity.

Phase I of SEARCH (2013-2017) showed that multi-disease, community-based testing and treatment is effective and can reduce deaths and new HIV infections and increase workforce participation.

 

Phase II (2017-2020) is focusing on new  health and treatment models for adolescents and young adults; HIV Pre-Exposure Prophylaxis (PrEP); treatment models for tuberculosis; and novel electronic technologies for community health.

PEOPLE

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Study Vice-Chair / Investigator

Edwin Charlebois, MPH, PhD

University of California, San Francisco

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Executive Administrator / Investigator

Tamara Clark, MHS

University of California, San Francisco

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Study Statistician / Investigator

Laura Balzer, PhD

Amherst University

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Kenya Site PI / Investigator

Elizabeth Bukusi, MBChB, M.Med, MPH, PhD

Kenya Medical Research Institute

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Investigator

Craig Cohen, MD, MPH

University of California, San Francisco

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Investigator

Gabriel Chamie, MD, MPH

University of California, San Francisco

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Economist / Investigator 

Harsha Thurimurthy, PhD

University of Pennsylvania

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Investigator

James Ayieko, MBChB, MPH

Kenya Medical Research Institute

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Investigator

Dalsone Kwarisiima, MBChB, MPH

Infectious Diseases Research Colaboration, Uganda

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Investigator

Lillian Brown, MD, PhD

University of California, San Francisco

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Investigator

Vivek Jain, MD, MAS

University of California, San Fracisco

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Investigator

Carol Camlin, PhD, MPH

University of California, San Francisco

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Investigator

Theodore Ruel, MD

University of California, San Francisco

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Investigator

Starley Shade, PhD, MPH

University of California, San Francisco

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Investigator

Catherine Koss, MD

University of California, San Francisco

Leadership
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Professor of Medicine and Chief, Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General Hospital, UC San Francisco

Principal Investigator

Diane Havlir, MD

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Professor of Medicine and current Chair of the Department of Medicine at Makerere University College of Health Sciences in Kampala, Uganda

Co-Principal Investigator

Moses Kamya, MBChB, MMed, MPH, PhD

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Associate Professor of Biostatistics and Epidemiology at the School of Public Health of the University of California, Berkeley

Co-Principal Investigator

Maya Petersen, MD, PhD

Investigative Team

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